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Research in the O’Donnell lab focuses on the molecular mechanism underlying selective protein trafficking. Specifically, we use studies of alpha-arrestins, a recently identified class of trafficking adaptor, to define key events in molecular selection and post-translational regulation of protein trafficking, as well as to define previously uncharacterized protein trafficking pathways. Our work uses the budding yeast Saccharomyces cerevisiae as a model system and we are currently applying insights from yeast to guide directed studies in mammalian cells.