Patrick Thibodeau, PhD

  • Assistant Professor, Department of Microbiology and Molecular Genetics

Contact Information

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Research Interests

My research is focused on understanding how protein folding underlies human disease with a focus on ATP-Binding Cassette (ABC-) proteins.  Studies in my laboratory explore the relationships between primary amino acid sequence and the acquisition of native protein structure and function and are focussed on cystic fibrosis (CFTR) and pseudoxanthoma elasticum (ABCC6).  We utilize a combination of structural, biophysical and cell biological approaches to elucidate the folding pathways of the wildtype proteins and their alteration by mutation.