Ron Wetzel, PhD

  • Professor, Department of Structural Biology

Contact Information

View departmental profile

Research Interests

We study the mechanisms of misfolding and misassembly of medically relevant peptides into multimers, various kinds of oligomers and amyloid fibrils, and in several ways are probing the relevance of these assembly states to neurodegeneration in Huntington's disease and Alzheimer's disease.  We are developing mutated forms of these peptides that alter aggregation pathways in cis and in trans that can be used to probe the toxicity of various assembled states in cell and animal models.  We have also been using advanced fluorescence techniques and other methods to directly determine the growth time dependent levels of various assembly states in dysfunctional and dying cells.