Amantha Thathiah, PhD

The focus of the research in the Thathiah lab is to study the cellular and molecular mechanisms involved in the pathogenesis of Alzheimer´s disease (AD). Neuropathologically, the brains of AD patients are characterized by the accumulation of aggregates of the amyloid-β (Aβ) peptide and neurofibrillary tangles, which are composed of the hyperphosphorylated microtubule-associated protein tau. The Thathiah lab investigates the involvement of G protein-coupled receptors (GPCRs) in modulation Aβ and tau pathology and the cross-talk between Aβ and tau in disease progression. We combine cellular and biochemical techniques with mouse models of neurodegeneration and behavioral studies to address our research questions.